Development of Sustained Release Tablet containing Antidiabetic Agent

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Artikelnummer:
613650
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    Development of Sustained Release Tablet containing Antidiabetic Agent

    The overall objective of the present work was to develop an oral sustained release Metformin tablet prepared by direct compression method using Hydroxypropylmethyl cellulose and Xanthan gum in different proportions. Nine formulations (T1-T9) were prepared. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. The dissolution study was performed as per USP-32 NF-27. The initial burst release was minimized by optimizing the concentration of xanthan gum. Then the concentration of HPMC was varied, keeping the concentration of xanthan gum fixed. From the dissolution study of nine batches, T8 was found to be the optimized batch capable to sustain the drug release for 10 hrs as it follows the dissolution parameter mentioned in USP-32 NF-27. The drug release kinetics shows that the T8 batch followed first order kinetics.
  • Zusatzinformation

    Autor
    Bindung
    Taschenbuch
    Verlag
    LAP Lambert Academic Publishing
    ISBN / EAN
    9783659274596
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